Beilstein J. Org. Chem.2017,13, 495–501, doi:10.3762/bjoc.13.49
ARTD2 catalysed PAR production [24]. After the times indicated, copper-catalysed clickconjugations to a fluorophore-containing azide were performed and the reactions were analysed by SDS PAGE. Then, fluorescent signals were detected and compared to the Coomassie Blue stained gels (Figure 2). Each
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Graphical Abstract
Figure 1:
NAD+ is used as a substrate by ARTDs to form MARylated and PARylated proteins. Depicted are alkyne-...
Beilstein J. Org. Chem.2014,10, 1325–1332, doi:10.3762/bjoc.10.134
hydroamination/glycosylation on glycal scaffolds has been developed to form propargyl 3-tosylamino-2,3-dideoxysugars in a one-pot manner. Subsequent construction of multivalent 3-tosylamino-2,3-dideoxyneoglycoconjugates with potential biochemical applications was presented herein involving clickconjugations as
the key reaction step. The copper-catalyzed regioselective click reaction was tremendously accelerated with assistance of microwave irradiation.
Keywords: clickconjugations; copper-catalyzed; microwave irradiation; multivalent glycosystems; neoglycoconjugates; one-pot; Introduction
Oligosaccharides
/glycosylation of the glycal shown in Figure 1 [49][50][51][52][53]. Extending the synthetic utility of this protocol, herein, we wish to report the synthetic modification of α-GalNAc-linked glycopeptides to 3-tosylamino-2,3-dideoxyneoglycoconjugates via clickconjugations (Figure 2).
Given the success in using
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Graphical Abstract
Figure 1:
Our reported strategy for quick access to 3-amino-2,3-dideoxysugars via regio- and stereoselective ...